Mitochondria and Sporadic Neurodegenerative Disease
نویسندگان
چکیده
منابع مشابه
Slower Dynamics and Aged Mitochondria in Sporadic Alzheimer's Disease
Sporadic Alzheimer's disease corresponds to 95% of cases whose origin is multifactorial and elusive. Mitochondrial dysfunction is a major feature of Alzheimer's pathology, which might be one of the early events that trigger downstream principal events. Here, we show that multiple genes that control mitochondrial homeostasis, including fission and fusion, are downregulated in Alzheimer's patient...
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To the Editor: Guerreiro et al.1 and Jonsson et al.2 (Jan. 10 issue) report an association between the single-nucleotide polymorphism (SNP) rs75932628 in the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) (predicting an R47H substitution) and Alzheimer’s disease in persons of European ancestry. We and other members of the Alzheimer’s Disease Genetics Consortium assem...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2012
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2011.11.027